# Ipamorelin reading list

> Lifted Peptides source list — The Lifted Peptides reading list: ipamorelin's founding experiments, human pharmacology, bowel-resection trial and selected animal and safety literature.

**Reading list**

The surgical trial is the paper I’d start with. Its practical ambition gives the earlier laboratory work a different perspective.

## Suggested starting points

Begin with [the randomized bowel-resection trial](https://pubmed.ncbi.nlm.nih.gov/25331030/), then turn back to [ipamorelin’s founding characterization](https://pubmed.ncbi.nlm.nih.gov/9849822/) and [the healthy-male-volunteer study](https://pubmed.ncbi.nlm.nih.gov/10496658/). That sequence moves from the clinical question to the selective hormone response.

The animal papers on [skeletal mineral content](https://pubmed.ncbi.nlm.nih.gov/10828840/) and [cisplatin-associated weight loss in ferrets](https://pubmed.ncbi.nlm.nih.gov/39043357/) are especially useful companions. The [cardiovascular paper](https://pubmed.ncbi.nlm.nih.gov/25722321/) concerns a different ghrelin-receptor agonist in rats. The ghrelin review supplies class context, and the later reviews offer broader safety assessments.

## References

[1] Ipamorelin, the first selective growth hormone secretagogue https://pubmed.ncbi.nlm.nih.gov/9849822/
[2] Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers https://pubmed.ncbi.nlm.nih.gov/10496658/
[3] Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus https://pubmed.ncbi.nlm.nih.gov/19289567/
[4] Prospective, randomized, controlled, proof-of-concept study of the ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients https://pubmed.ncbi.nlm.nih.gov/25331030/
[5] Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats https://pubmed.ncbi.nlm.nih.gov/10373343/
[6] The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats https://pubmed.ncbi.nlm.nih.gov/10828840/
[7] The growth hormone secretagogue receptor 1a agonists, anamorelin and ipamorelin, inhibit cisplatin-induced weight loss in ferrets: Anamorelin also exhibits anti-emetic effects via a central mechanism https://pubmed.ncbi.nlm.nih.gov/39043357/
[8] Integrated approach to early detection of cardiovascular toxicity induced by a ghrelin receptor agonist https://pubmed.ncbi.nlm.nih.gov/25722321/
[9] Therapeutic peptides in gerontology: mechanisms and applications for healthy aging https://doi.org/10.3389/fragi.2026.1790247
[10] Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance https://doi.org/10.1007/s40279-026-02437-0
[11] Actions and therapeutic pathways of ghrelin for gastrointestinal disorders https://doi.org/10.1038/nrgastro.2009.72

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At Lifted Peptides I follow ipamorelin from a lifted hormone signal to the practical outcomes in published research, with curiosity to spare and no medical advice to give.